Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated

Abstract Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along with investigating how T1D influences increases other cells (hematopoietic cells; HPCs) and surface expression chemokine receptor 4 (CXCR4) 7 (CXCR7), needed. Thirty patients 30 matched non-diabetes controls completed 45 min incline walking. Circulating HPCs (CD34 + , CD34 CD45 dim ) EPCs VEGFR2 ), subsequent CXCR4 CXCR7, were enumerated by flow cytometry at rest post-exercise. Counts HPCs, CXCR7 significantly lower the group. In both groups, exercise increased circulating cells. was largely attenuated group, up to 55% lower, (331 ± 437 Δcells/mL vs. 734 876 p = 0.048), (171 342 303 267 Δcells/mL, 0.006) (126 242 218 217 0.040) lower. Exercise-induced possible patients, albeit compared controls. Decreased mobilization likely results reduced migration to, repair of, damage, potentially limiting cardiovascular benefits exercise. Trial registration: ISRCTN63739203.